Nicole Brennan was a Senior Medical Officer of the USG Ishimura during the Second Aegis VII Incident. An initial survivor of the Necromorph outbreak aboard the Ishimura during the Second Necromorph War, Nicole tried to help save as many survivors as she possibly could. Nicole's personality was a strong person, but when pushed to the edge, constantly breaks down in the midst the chaos. During the events on Aegis VII and the Ishimura, Nicole remains dedicated to her job and to the welfare of crewmen and colonists alike. Friendly, she befriends the likes of Lexine’s party in spite of their position as stowaways who broke the no-fly order issued by Captain Mathius.