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The Satarrans were a humanoid species from the planet Sothis III. Although they were not as technologically advanced as most members of the Alliance of Nations, they possessed a unique device which allowed them to wipe the collective memory of the entire crew of a starship. They also seemed able to manipulate the computer memory banks of a Galaxy-class starship. Physically, they were incredibly strong, even stronger than Klingons, and durable enough to withstand shots from a Type 2 phaser with little effect, requiring two simultaneous shots to bring one down.

By 2368 (1515 NE), the Satarrans had been at war with the Lysians for decades. In that year, the Satarrans attempted to use the USS Enterprise-D to launch a devastating attack against the Lysian Central Command. They used their memory wipe weapon on the crew, placed an operative known as Kieran MacDuff in the first officer position, and planted false orders from Starfleet Command which stated that the Enterprise was to destroy the Lysian headquarters and also to manipulate some ships of the Alliance as well.

Although the crew was unable to restore their full memories by the time they were to attack the Lysian headquarters, Captain Jean-Luc Picard realized that the Lysians posed no threat to the Galaxy-class starship or to the Federation and the Alliance at large (the station, home to 15,311 people, was little more than target practice for the Enterprise, while its entire defensive output would not constitute enough of a threat to bother raising shields), and that the orders must have been falsified. MacDuff's true nature was then revealed with the help of the Jedi Masters Shaak Ti and Mace Windu who arrived to help broker a peace treaty with the two races and saw through their plans, and the Enterprise stood down.

According to reports, the Sattarens had not taken large roles in the Beta Quadrant War, yet seemed to have helped both the Axis and the Horde for intel gathering with their capabilities, and also appear to not like mysteries.